HIV-1 gp160 C1, V1/V2, and the CD4-binding domains are required for its binding to protein-disulfide isomerase (PDI) Treatment of trimeric HIV-1 rgp140 with protein disulfide isomerase yields monomers by disruption of the intermolecular disulfide bonds HIV-1 gp160 co-localizes with the endoplasmic reticulum protein PDI in HIV-transfected 293T cells HIV-1 gp160 interacts with PDIA2 predicted interaction to be within the endoplasmic reticulum and function as thioredoxin reductase The disulfide cross-linking interaction between gp120 and PDI is enhanced by CD4 proteinĮnvelope surface glycoprotein gp160, precursor Protein-disulfide isomerase (PDI) cleaves disulfide bonds in recombinant HIV-1 envelope glycoprotein gp120, and gp120 bound to the surface receptor CD4 undergoes a disulfide reduction that is prevented by PDI inhibitors PDI is predominantly involved in HIV-1 entry and infection of the T cell line PM-1 and PHA-stimulated primary T lymphocytes, suggesting the preferential use of PDI relevant to the HIV-1 entry and establishment of virus reservoirs in resting CD4+ cells

HIV-1 gp120 co-localizes with the endoplasmic reticulum protein PDI in HIV-transfected 293T cells Expression Biased expression in pancreas (RPKM 284.3) and stomach (RPKM 33.5) See more Orthologs mouse all NEW Try the new Gene table The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels.

The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. Full Name protein disulfide isomerase family A member 2 provided by HGNC Primary source HGNC:HGNC:14180 See related Ensembl:ENSG00000185615 MIM:608012 AllianceGenome:HGNC:14180 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as PDI PDA2 PDIP PDIR Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions.

Pdi p56784